منابع مشابه
Sugar phosphate phosphohydrolase. II. Effects of glucose on its activity and biosynthesis in Neisseria meningitidis.
The sugar phosphate phosphohydrolase activity of Neisseria meningitidis could be significantly repressed by a glucose concentration of 5.5 X lop4 M, and a half-maximal repression was seen with 1.5 X low3 M glucose under the experimental conditions used. This restraint was independent of the Pi concentration, did not require Mg++, Mn++ Fe+++, Na+, K+, or NH4+, and exhibited no correlation with t...
متن کاملCharacterization of murine sphingosine-1-phosphate phosphohydrolase.
In the present study we have characterized mammalian sphingosine-1-phosphate phosphohydrolase (SPP1), an enzyme that specifically dephosphorylates sphingosine 1-phosphate (S1P) and which differs from previously described lipid phosphate phosphohydrolases. Based on sequence homology to murine SPP1, we cloned the human homolog. Transfection of human embryonic kidney 293 and Chinese hamster ovary ...
متن کاملPulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.
The lung contains two distinct forms of phosphatidic acid phosphatase (PAP). PAP1 is a cytosolic enzyme that is activated through fatty acid-induced translocation to the endoplasmic reticulum, where it converts phosphatidic acid (PA) to diacylglycerol (DAG) for the biosynthesis of phospholipids and neutral lipids. PAP1 is Mg(2+) dependent and sulfhydryl reagent sensitive. PAP2 is a six-transmem...
متن کاملPulmonary lipid phosphate phosphohydrolase in plasma membrane signalling platforms.
Lipid phosphate phosphohydrolase (LPP) has recently been proposed to have roles in signal transduction, acting sequentially to phospholipase D (PLD) and in attenuating the effects of phospholipid growth factors on cellular proliferation. In this study, LPP activity is reported to be enriched in lipid-rich signalling platforms isolated from rat lung tissue, isolated rat type II cells and type II...
متن کاملLipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters.
Lipid phosphate phosphohydrolase (LPP)-1 cDNA was cloned from a rat liver cDNA library. It codes for a 32-kDa protein that shares 87 and 82% amino acid sequence identities with putative products of murine and human LPP-1 cDNAs, respectively. Membrane fractions of rat2 fibroblasts that stably expressed mouse or rat LPP-1 exhibited 3.1-3. 6-fold higher specific activities for phosphatidate dephos...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1969
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)91742-4